A 25-year-old carpenter notices the appearance of several hyperkeratotic papules (warts) on the palm side of his index finger. They do not change in size and cause him only minimal discomfort. After a year, they spontaneously disappear.
1. Will this virus infection spread to other body sites?
2. After its disappearance, is the infection likely to be completely resolved or to persist in the host?
3. What viral, cellular, and host conditions regulate the replication of this virus and other HPVs?
4. How would the papillomavirus type causing this infection be identified?
5. Is it likely that this type of HPV is associated with human cancer? If not, which types are associated with cancers, and which cancers are they?
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