A 40-year-man weighing 60 kg suffering from chronic co ugh with expectoration a nd fever was diagnosed to have cavitary pulmonary tuberculosis. He was put on the standard 1st line antitubercular...

A 40-year-man weighing 60 kg suffering from chronic co ugh with expectoration a nd fever was diagnosed to have cavitary pulmonary tuberculosis. He was put on the standard 1st line antitubercular regimen consisting of isoniazid (H) + rifampin (R) + pyrazinamide (Z) + ethambutol (E). His condition improved, but in the 4th week he developed jaundice with e nlarged tender liver and rise in serum bilirubin as well as serum transaminase levels. He was suspected to have developed antitubercular drug induced he patitis. (a) Should his antitubercular treatment be stopped or continued? (b) How wo uld you proceed to confirm and identify the causative drug, and then select t he alternative regimen?