1.- Describe the pharmacology of heroin, what are the key metabolites detected during toxicological analysis of heroin use and what are the physiological causes and symptoms of heroin overdose?...

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1.- Describe the pharmacology of heroin, what are the key metabolites detected during toxicological analysis of heroin use and what are the physiological causes and symptoms of heroin overdose? 2.- A motorist has an accident at 02:30 hours but leaves the scene and returns home. The police trace him, and a blood sample is taken at 08:45 hours. Analysis reveals a blood alcohol concentration of 68 milligrams per 100 millilitres (mg%). The man says he had been drinking until about 01:00 hours and had then talked with friends before setting off to drive home where he had an accident. He says he panicked because he knew he’d been drinking and fled from the scene. Use an average elimination rate of 19 mg%/hour and a range 9 to 27 mg%/hour to calculate his lowest, most likely and highest Blood Alcohol Concentration (BAC) (i)What would his blood alcohol concentration have been at the time of the accident? Include the possible range in your answer. (ii)Is the back-calculation likely to be valid? 3.- A motorist is arrested and is subjected to a roadside oral screen. The screen returns a positive for cocaine at the roadside preliminary test. The motorist is arrested for violation of Section 5a of the road traffic act. A blood sample is taken and sent for toxicology analysis for drugs and alcohol. A confirmation test reveals a blood concentration of the following: Analyte Concentration (ng/ml) (g/L) THC 2.5 Benzoylecgonine 80 Cocaethylene 35 These results represent the analytical results and must be subjected to a 20% uncertainty for cocaine, a 30% uncertainty for benzoylecgonine and 15% uncertainty for nordiazepam. What are the limits of section 5a for the above drugs and from your calculations what if any limits of Section 5a has the motorist exceeded? 4.- A motorist is arrested and is subjected to a roadside oral screen. The screen returns a positive for cocaine at the roadside preliminary test. The motorist is arrested for violation of Section 5a of the Road Traffic Act. A blood sample is taken and sent for toxicology analysis for drugs and alcohol. A confirmation test reveals blood concentrations of the following analytes: Analyte Concentration (ng/ml) (ug/L) Cocaine 6 Benzoylecgonine 58 Cocaethylene 35 These represent the analytical results and must be subjected to a 20% uncertainty for cocaine, a 30% uncertainty for benzoylecgonine and 15% for cocaethylene. What are the limits in Section 5a for the above drugs and from your calculations what, if any limits of Section 5a, has the motorist exceeded?