In E. Coli, under high lactose, high glucose conditions, which of the following could lead to maximal transcription activation of the lac operon?
(A) A mutation in the lac I gene (which encodes the repressor)
(B) A mutation in the CRP binding site leading to enhanced binding
(C) A mutation in the operator sequence
(D) A mutation leading to enhanced cAMP levels
(E) A mutation leading to lower binding of repressor
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