THE LINK FOR THE RESEARCH PAPER IS https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902775/ Please click on the banner that says "JAMA network Open" at the very top to view the paper required to read to...

Running head: HEALTHCARE
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HEALTHCARE
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1.1
The research objective of the study is to assess the effectiveness of naloxone dosage, which was administered through the intranasal path in comparison to the intramuscular injection of naloxone overdosage while opioid reversing. The participants in the study were youth of eighteen years of age or older who had a history of drug usage. The intervention on the participants was through administering naloxone, either intramuscular or intranasal path was used. The comparison was to assess the effectiveness of both the ways of administering the drugs to the participants.
The outcomes that were measured had two findings from the research study. The first finding or outcome of the dosage through intranasal path showed the time of respiration rate inadequate time to be greater or equal to ten breaths taken by the participants in a range of one minute. The second finding or the outcome of the study presented that there was a requirement of dosage for rescue in case of an intramuscular dose of naloxone. The primary objective was to treat the participants from the overdosage of opioid.
2.1.
Yes, the method of allocation to treatment groups was randomized in the research study. This is evident when we see the process of randomly choosing the participants in the setting of the study. The participants were recruited by the MSIC located in Sydney. They were randomly chosen for the study as they had the history of injecting or taking drugs either through the nasal path or through intramuscular injections. The participants were of the age of eighteen or above that, who willingly appeared for the research study.
The participants have registered with the MSIC for the research study. Medically Supervised Injecting Center provides service o with the clients those who are economically and socially deprived. The participants did not have any contact with the generator or the executors of the research study team. The participants were nurses, and the youth who registered themselves with the centre were blinded. The researchers were double-blinded with the two treatment arms in the study. There it can be safely justified that the participants chosen for the clinical study were randomized.
2.2.
Yes, the method of allocation was concealed. The primary schedule of randomization had the labelled placebo with the active packs of naloxone that was provided by the packer of the drugs. The vials that were used for the research study were all concealed and computer code. The company prepared the naloxone and placebo to be used in two batches. The method of allocation was concealed as the trial of the study was ethically approved with the double-blinded participants for the research study team.
The vials...