Todo et al. (2013) obtained the data shown in the table for the diffusion of methylparaben (MP) across a silicone membrane proposed as an alternative to the use of an animal skin for the prediction of...

Todo et al. (2013) obtained the data shown in the table for the diffusion of methylparaben (MP) across a silicone membrane proposed as an alternative to the use of an animal skin for the prediction of skin permeation. MP is a preservative that is found in a variety of cosmetics and other personal care products. The molecular weight of MP is 152.2. The concentration of MP in the donor compartment was 10 mM, or 1522 μg cm⁻³. From these data, estimate the permeability of MP in the silicone membrane.