Transporter test systems have varied expression of transporters., For example, an overexpressing test system (e.g., MDR1-MDCK) may have higher functional activity for P-gp than a cell line derived...

Transporter test systems have varied expression of transporters., For example, an overexpressing test system (e.g., MDR1-MDCK) may have higher functional activity for P-gp than a cell line derived from a relevant organ phenotype (e.g., Caco-2). What effects and/or difference would you expect when assessing substrate potential and inhibition potential in each of these in vitro models?