Consider Michael Lynch’s hypothesis that mutation rates are determined by an interplay between natural selection and genetic drift. Now imagine an experiment in which you keep many different...

Consider Michael Lynch’s hypothesis that mutation rates are determined by an interplay between natural selection and genetic drift. Now imagine an experiment in which you keep many different populations of E. coli bacteria, each at a different effective population size, for many thousands of generations. How would Lynch’s hypothesis predict that mutation rates would evolve in populations of different sizes?