Example Modification Table Modification Location Effect on Transcription Modifier Interpreter H3K123 monometh di/trimeth Promoter Gene Body Promoter Activation Repression and Alt splicing Activation...

An example table is posted below for your reference.

Chapter 4

DNA methyltransferases
, also called
MTases

cell cycle-regulated methylase (CcrM)

DNA cytosine methyltransferase (Dcm)

de novo


methyltransferases

De novo DNA methylation

Chapter 5

H3K9me and H3K9me2

Histone ubiquitination

Histone phosphorylation

Histone methylation/demethylation

_ I attached a file of the table for example

Example Modification Table Modification Location Effect on Transcription Modifier Interpreter H3K123 monometh di/trimeth Promoter Gene Body Promoter Activation Repression and Alt splicing Activation Fake1 and many proteins containing Stupid domain ???? Fake1 complexed with Real1 HAT456 acetylates region HP1 binds this modification Stabilizes Mediator, blocks H3K789 methylation. H3K133 mono/dimeth trimeth Promoter 3’UTR Promoter Repression Activation Activation by Elongation Whodat and Whodat2 Whatsit Complex ???? DNMT99 binds and methylates DNA ???? Something stabilizes RNA Pol, unknown Epigenetics in Health and Disease Book by Igor Kovalchuk and Olga Kovalchuk (2012) You are going to build a group summary of each modification listed in these two chapters 4 and 5 (in Table format).  Include information on the effect (including where in the gene the modification has the effect) and any mechanisms that appear to be known.  Of KEY IMPORTANCE are any proteins that interpret the modification and actually bring about an effect. Order them however makes the most sense to you.  Post your final group summary on the Modification Summary general discussion board when your group is finished (on Wednesday).  An example table is posted below for your reference. SPECIFIC READING INSTRUCTIONS - In chapter 4, skip the entire section on "DNA Adenine Methytransferase (DAM)."  Begin again  with Eukaryotic Methylation and end at "Cytosine Methylation in Plants." (We will not be focusing on plants in this course.) In chapter 5, read from the beginning and stop at the part titled "Patterns of Histone . . . Interphase Nucleus."  The information on patterns of acetylation in the nuclear architecture model is garbled and a bit too contradictory for my tastes, so I elected to skip this (along with the plant portion once again). Chapter 4 DNA methyltransferases, also called MTases cell cycle-regulated methylase (CcrM) DNA cytosine methyltransferase (Dcm) de novo methyltransferases De novo DNA methylation Chapter 5 H3K9me and H3K9me2 Histone ubiquitination Histone phosphorylation Histone methylation/demethylation