1. A 13-year-old boy su ering from acute lym phoblastic leukem ia was adm itted to the hospital for the third cycle of anticancer therapy, w hich included high-dose m ethotrexate. W hich of the follow...

1. A 13-year-old boy su ering from acute lym phoblastic leukem ia was adm itted to the hospital for the third cycle of anticancer therapy, w hich included high-dose m ethotrexate. W hich of the follow ing drugs should be given to the patient to counteract m ethotrexate toxicity? A. Folic acid B. Cyanocobalam in C. Leucovorin D. Ferrous sulfate E. Oprelvekin F. Filgrastim 2. A 39-year-old m ale AIDS patient has had recent episodes of cytom egalovirus esophagitis. The m an was being treated w ith a zidovudine, lam ivudine, efavirenz com bination for AIDS and w ith ganciclovir for cytom egalovirus prophylaxis. His last blood analysis revealed the follow ing: red blood cell count 4.1 × 106/mm3 (norm al, m ale 4.3-5.9 × 106/mm3), w hite blood cell count 1.5 × 103/mm3 (norm al 4.5-11.0 × 106/mm3), neutrophil count 250/m m3 (norm al 3000-7000/ m m3). Which of the follow ing drugs would be appropriate to add to the patient’s therapeutic regim en at this tim e? A. Erythropoietin B. Saquinavir C. Cyanocobalam in D. Filgrastim E. Ferrous sulfate