1. A 20-year-old m an, diagnosed w ith acute rheum atic fever, started high-dose salicylate treatm ent. A few days later, laboratory values indicated increased blood pH, decreased P a CO2, and...

1. A 20-year-old m an, diagnosed w ith acute rheum atic fever, started high-dose salicylate treatm ent. A few days later, laboratory values indicated increased blood pH, decreased P a CO2, and decreased plasm a bicarbonate content. Which of the follow ing acid-base disturbances was m ost likely caused by salicylate treatm ent? A. Respiratory acidosis B. Respiratory alkalosis C. Metabolic acidosis D. Metabolic alkalosis E. Mixed acidosis 2. A 54-year-old m an presented to the em ergency departm ent w ith nausea, headache, dizziness, tinnitus, di cult y in hearing, and sweating. His body tem perature was 103.1°F (39.5°C). The patient was su ering from osteoarthritis and had been overtreating him self w ith aspirin for 4 days in an attem pt to relieve severe pain in his right hip. Which of the follow ing actions m ost likely m ediated the drug-induced hypertherm ia in this patient? A. Resetting the hypothalam ic therm ostat B. In am m atory reaction in the joints C. Increased release of interleukin-10 D. Uncoupling oxidative phosphorylation in skeletal m uscle E. Metabolic alkalosis