1. A 24-year-old wom an experienced severe m otion sickness w henever she traveled by air or sea. Diphenhydram ine taken before a trip was e ective in m inim izing her sym ptom s. The therapeutic e...

1. A 24-year-old wom an experienced severe m otion sickness w henever she traveled by air or sea. Diphenhydram ine taken before a trip was e ective in m inim izing her sym ptom s. The therapeutic e ect of the drug was m ost likely due to blockade of w hich of the follow ing pairs of central receptors? A. Dopam inergic and ß-adrenergic B. GABAergic and serotonergic C. Alpha-adrenergic and m uscarinic D. Histam inergic and m uscarinic E. Serotonergic and peptidergic 2. A 33-year-old wom an was hospitalized after 1 week of increasing pain, tenderness, and cyanosis in her legs. She adm itted to taking several m edications to relieve a m igraine headache. Physical exam ination revealed that no pulses could be palpated below the fem oral vessels, and an aortogram showed a pronounced constriction of the vessels distal to the iliac arteries. The vasoconstriction disappeared after 3 hours of nitroprusside intravenous infusion. Which of the follow - ing drugs m ost likely caused the vessel constriction? A. Aspirin B. Propranolol C. Ergotam ine D. Acetam inophen E. Naproxen F. Diclofenac