1. A 43-year-old m an w ho underwent a kidney transplant had been receiving an im m unosuppressive treatm ent that included a m acrolide antibiotic. The drug binds to a FK-binding proteins located in...

1. A 43-year-old m an w ho underwent a kidney transplant had been receiving an im m unosuppressive treatm ent that included a m acrolide antibiotic. The drug binds to a FK-binding proteins located in T cells, thus blocking gene expression for production of several cytokines. Which of the follow ing drugs m ost likely works w ith this m echanism of action? A. Azithromycin B. Azathioprine C. Tacrolim us D. Cyclosporine E. Tobramycin376 In ammation and Immunomodulation 2. A 42-year-old wom an who underwent a liver transplant com - plained of nausea and vom iting, severe abdom inal pain, and diarrhea 1 week after the surgery. The patient had been receiving a m ultidrug im m unosuppressive therapy. If the patient’s sym ptom s were drug-related, w hich of the follow ing drugs m ost likely caused the reported adverse e ects? A. Etanercept B. Mycophenolate m ofetil C. Doxorubicin D. Le unom ide E. Paclitaxel F. Fluorouracil