1. A 44-year-old wom an su ering from rheum atoid arthritis recently had le unom ide added to her m ethotrexate therapy. Inhibition of w hich of the follow ing enzym es m ost likely m ediated the...

1. A 44-year-old wom an su ering from rheum atoid arthritis recently had le unom ide added to her m ethotrexate therapy. Inhibition of w hich of the follow ing enzym es m ost likely m ediated the therapeutic e ect of the drug in the patient’s disease? A. Cyclooxygenase-1 B. Type II topoisom erase C. Dihydrofolate reductase D. Dihydroorotate dehydrogenase E. Reverse transcriptase F. Peptidyl transferase 2. A 55-year-old m an com plained to his physician that a rash had appeared the previous day on his thorax and legs. The patient was recently diagnosed w ith hyperuricem ia and had been receiving allopurinol for 2 weeks. The physician suspected the rash was due to the ongoing pharm acotherapy and decided to discontinue allopurinol and to start a treatm ent w ith probenecid. The physician should advise the patient not to concurrently use w hich of the follow ing drugs? A. Acetam inophen B. Ibuprofen C. Phenylephrine D. Aspirin E. Loratadine F. Diphenhydramine