1. A 45-year-old w om an w ho underw ent a liver transplant started an im m unosuppressive therapy that included tacrolim us. The risk of w hich of the follow ing drug-related disorders was m ost...

1. A 45-year-old w om an w ho underw ent a liver transplant started an im m unosuppressive therapy that included tacrolim us. The risk of w hich of the follow ing drug-related disorders was m ost likely increased in this patient? A. Hypotension B. Hypokalem ia C. Hypoglycem ia D. Hem olytic anem ia E. Neurotoxicity 2. A 51-year-old m an presented to the clinic w ith com plaints of an enlarged, painful lym ph node in his groin. One year earlier, he had undergone surgical resection of stage 2 m alignant m elanom a. A lym ph node biopsy con rm ed the recurrence of m alignant m elanom a. The patient started a course of chem otherapy that included the intravenous adm inistration of aldesleukin. Which of the follow ing m olecular actions m ost likely m ediated the therapeutic e ect of the drug in the patient’s disorder? A. Proliferation and di erentiation of B and T lym phocytes B. Inhibition of m acrophage phagocytic activity C. Inhibition of antigen presentation by dendritic cells D. Decreased synthesis of calcineurin E. Inhibition of activity of natural killer cells