1. A 46-year-old wom an recently diagnosed w ith classic m igraine had a headache attack at least once a week. Ergotam ine was prescribed to prevent the im pending attacks. Which of the follow ing...

1. A 46-year-old wom an recently diagnosed w ith classic m igraine had a headache attack at least once a week. Ergotam ine was prescribed to prevent the im pending attacks. Which of the follow ing actions m ost likely contributed to the therapeutic e ect of the drug in the patient’s disorder? A. Constriction of cerebral vessels B. Extravasation of plasm a into perivascular space C. Prostaglandin release from vascular endothelium D. Platelet aggregation in the cerebral vascular bed E. Increased ring of trigem inal neurons