1. A 50-year-old wom an w ith rheum atoid arthritis was recently diagnosed w ith refractory disease, and in ixim ab was added to her ongoing treatm ent. Which of the follow ing endogenous com pounds...

1. A 50-year-old wom an w ith rheum atoid arthritis was recently diagnosed w ith refractory disease, and in ixim ab was added to her ongoing treatm ent. Which of the follow ing endogenous com pounds was m ost likely the m olecular target of the drug? A. Interleukin-1 B. Vascular endothelial grow th factor C. Interleukin-10 D. Epiderm al grow th factor E. Tum or necrosis factor-a 2. A 48-year-old m an was adm itted to the em ergency departm ent w ith the chief com plaint of an excruciating pain in his left ankle. The pain had started the previous night and increased over several hours. The patient reported that he sprained his ankle 1 week ago. On physical exam ination, the ankle appeared warm and tender, and the entire area was red and swollen. A synovial uid analysis showed crystals engulfed by phagocytes. A diagnosis was m ade, and a pharm acotherapy was prescribed. Which of the follow ing drugs would be m ost appropriate to treat the patient’s pain? A. Codeine B. Indom ethacin C. Methotrexate D. Aspirin E. Etanercept F. Allopurinol