1. A 53-year-old m an w ho underwent liver transplantation for advanced biliary cirrhosis had been receiving im m unosuppression treatm ent w ith prednisone and cyclosporine. Despite the therapy, a...

1. A 53-year-old m an w ho underwent liver transplantation for advanced biliary cirrhosis had been receiving im m unosuppression treatm ent w ith prednisone and cyclosporine. Despite the therapy, a liver biopsy still showed rejection 14 days after surgery. Which of the follow ing drugs could be substituted for cyclosporine to treat this case of cyclosporineresistant rejection? A. Aldesleukin B. Vinblastine C. Tacrolim us D. Fluorouracil E. Paclitaxel 2. A 65-year-old w om an recently diagnosed w ith polym yositis had not im proved after 2 weeks of treatm ent w ith prednisone. A decision w as m ade to replace prednisone w ith an im m unosuppressive drug that acts by inhibiting enzym es essential for purine biosynthesis. W hich of the follow ing drugs was m ost likely prescribed? A. Etanercept B. Cyclosporine C. Tacrolim us D. Sirolim us E. Azathioprine F. In ixim ab