1. A 53-year-old m an w ith a heart transplant underwent im - m unosuppressive treatm ent that included oral cyclosporine. Which of the follow ing cells represent the m ain site of action of this...

1. A 53-year-old m an w ith a heart transplant underwent im - m unosuppressive treatm ent that included oral cyclosporine. Which of the follow ing cells represent the m ain site of action of this drug? A. Macrophages B. Dendritic cells C. T-helper cells D. Plasm a cells E. Natural killer cells 2. A 54-year-old wom an w ho underwent a kidney transplant developed nausea, vom iting, and diarrhea a few days after the surgery. The patient had received posttransplant therapy w ith cyclosporine and prednisone. A decision was m ade to substitute sirolim us for the cyclosporine. Which of the follow ing actions m ost likely m ediated the im m unosuppressive e ect of sirolim us? A. Stim ulation of the synthesis of tum or necrosis factor B. Stim ulation of B-cell proliferation C. Inhibition of histam ine release D. Inhibition of T-cell proliferation E. Inhibition of calcineurin