1. A 59-year-old obese wom an presented to the em ergency departm ent because of severe colicky pain in the right lum bar region. The patient had a long history of osteoarthritis and experienced...

1. A 59-year-old obese wom an presented to the em ergency departm ent because of severe colicky pain in the right lum bar region. The patient had a long history of osteoarthritis and experienced frequent episodes of strong arthritic pain for w hich she had been taking several di erent pain killers daily for the past year. Current m edications included atorvastatin and ezetim ibe for hyperlipidem ia and hydrochlorothiazide for m ild hypertension. A renal biopsy con rm ed the diagnosis of papillary necrosis and tubulointerstitial in am m ation of the kidney. Which of the follow ing drugs m ost likely caused the patient’s disease? A. Codeine B. Tram adol C. Diclofenac D. Hydrochlorotiazide E. Atorvastatin F. Ezetimibe