1. A 63-year-old hom eless m an was adm itted to the hospital w ith fever, general m alaise, and a swollen, painful leg. Physical exam ination showed a m an in obvious distress w ith the follow ing...

1. A 63-year-old hom eless m an was adm itted to the hospital w ith fever, general m alaise, and a swollen, painful leg. Physical exam ination showed a m an in obvious distress w ith the follow ing vital signs: blood pressure 88/50 m m Hg, heart rate 115 bpm , respirations 22/m in, tem perature 103.1°F (39.5°C). His right leg had a large wound and appeared swollen w ith a “bronze” discoloration and crepitation of the tissue. A presum ptive diagnosis was m ade. An em piric therapy was started that included extensive debridem ent of the wound and adm inistration of a drug that was able to cure the infection. The m echanism of action of the given drug m ost likely involved the inhibition of w hich of the follow ing bacterial enzym es? A. Acetyl transferase B. Beta-lactam ase C. Transpeptidase D. Autolytic enzym es E. Transglycosylase

May 08, 2022
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