1. This drug can inhibit both cyclooxygenase and phospholipase A2. 2. The analgesic e ect of this drug is prim arily m ediated by central im pairm ent of pain transm ission. 3. The long half-life of...

1. This drug can inhibit both cyclooxygenase and phospholipase A2. 2. The analgesic e ect of this drug is prim arily m ediated by central im pairm ent of pain transm ission. 3. The long half-life of this drug (m ore than 50 hours) perm its once-daily dosing. 4. The m other of a 17-m onth-old girl took the baby to the pediatrician because she found that her daughter’s rectal tem - perature was 103.1°F (39.5°C). After physical exam ination, the pediatrician said the fever was most likely due to a viral infection and prescribed ibuprofen. Which of the follow ing m olecular actions m ost likely m ediated the antipyretic e ect of the drug in this patient? A. Blockade of prostaglandin receptors in the hypothalam us B. Inhibition of phospholipase A2 in the hypothalam us C. Decreased interleukin concentration in the hypothalam us D. Decreased concentration of prostaglandins in the hypothalamus E. Inhibition of cyclooxygenase in peripheral tissues F. Blockade of oxidative phosphorylation in skeletal muscle