A 13-year-old girl presents because of increased thirst, hunger, and frequent urination over the past few months. Urinalysis discloses 3+ glucosuria. The blood sugar is 275 mg/dL. The patient receives...

A 13-year-old girl presents because of increased thirst, hunger, and frequent urination over the past few months. Urinalysis discloses 3+ glucosuria. The blood sugar is 275 mg/dL. The patient receives counseling on the selfadministration of insulin. Six years later, she complains of blurred vision. Ophthalmic examination reveals “snowflake” cataracts. An accumulation of which of the following biologic compounds best accounts for the pathogenesis of cataracts in this patient?

(A) Glycogen in the iris

(B) Hemoglobin in the lens

(C) Lipid in the lens

(D) Lipid in the retina

(E) Sorbitol in the lens