A 4-year-old boy presents with a white pupil that his parents first noticed about 4 months ago. A history of an eye tumor in a first cousin is provided. Ophthalmic examination shows a tumor in the...

A 4-year-old boy presents with a white pupil that his parents first noticed about 4 months ago. A history of an eye tumor in a first cousin is provided. Ophthalmic examination shows a tumor in the left eye (patient shown in the image), after which the eye is enucleated. A mutation in which of the following genes was most likely associated with the development of this tumor?

(A) p53

(B) C-myc

(C) N-myc

(D) Rb

(E) RET