A 65-year-old woman with a history of breast cancer and a recent melanoma presents to the emergency room following a tonic-clonic seizure. Blood chemistry values are within normal limits. There is no...

A 65-year-old woman with a history of breast cancer and a recent melanoma presents to the emergency room following a tonic-clonic seizure. Blood chemistry values are within normal limits. There is no history of drug or alcohol use. MRI of the brain shows bilateral cerebral edema and a cystic, frontal lobe lesion. Frozen section obtained from a CT-guided biopsy reveals a hemorrhagic nodule of neoplastic cells. Immunohistochemical stains for which of the following antigens would be most helpful in making your diagnosis definitive for melanoma?

(A) Alpha-fetoprotein

(B) HMB-45

(C) Human chorionic gonadotropin

(D) Neuron-specific enolase

(E) Synaptophysin