An 8-month-old boy exhibits severe motor, sensory, and cognitive impairments. Brain biopsy shows a disease of white matter characterized by the accumulation of “globoid cells.” Biochemical studies...

An 8-month-old boy exhibits severe motor, sensory, and cognitive impairments. Brain biopsy shows a disease of white matter characterized by the accumulation of “globoid cells.” Biochemical studies reveal an absence of galactocerebroside b-galactosidase activity. What is the appropriate diagnosis?

(A) Alexander disease

(B) Hurler disease

(C) Krabbe disease

(D) Metachromatic leukodystrophy

(E) Glycogen storage disease