RX 351 Lab - Module 6 Assignment (30pts) Name _______________________________________________________________Complete and submit on Canvas. You must show all work to receive full credit. Do not...

1 answer below »
Attached


RX 351 Lab - Module 6 Assignment (30pts) Name _______________________________________________________________ Complete and submit on Canvas. You must show all work to receive full credit. Do not leave off units and make sure to use leading zeros. Dropping units in your answer or failure to use a leading zero in an answer will result in no credit for that answer, even if the number itself is correct. Metronidazole is an antibiotic that is used orally, intravenously and topically. When compounding a pediatric oral suspension, it is typical to use metronidazole tablets as the source of the API, like in this formulation: Rx Metronidazole 500mg tablets Chocolate Flavoring Dark Cherry Flavoring Bitter Suppressant #10 5gtts 5gtts 2gtts Ora-Blend Vehicle qs ad 100ml 1. (2pts) How many metronidazole 500mg tablets would you need to prepare 8 fluid ounces of this suspension? 2. (2pts) If a pediatric patient takes ½ teaspoonful of this oral suspension q8h, how many milligrams of metronidazole will she receive per day? 3. (8pts) Refer to your textbook, Contemporary Pharmacy Practice, and read the sections on mortars and pestles in Chapter 13. Describe the different types of mortars. 4. (2pts) Which of the mortars would be a good choice to crush the tablets to prepare the metronidazole suspension? Explain your choice. 5. (2pts) Refer to Chapter 25 of your Contemporary Pharmacy Practice textbook, Section V. a. What is the general term for the process of reducing particle size? b. What is the term for reducing particle size in a mortar with a pestle? 6. (2pts) Metronidazole is a notoriously bitter-tasting drug. This recipe uses two flavorings and a bitter suppressant product to mitigate the bad taste. Refer to Chapter 20 in your Contemporary Pharmacy Practice textbook, Section II. What methods could the caregiver/parent of the child use to help with the bad taste? 7. (3pts) The ester form of metronidazole, metronidazole benzoate, does not have the same bitterness issue sue to its very low water solubility. Metronidazole benzoate is available in powder form. How many grams of metronidazole benzoate would be needed to prepare 8 fluid ounces of the formulation (above) such that the patient would receive an equivalent dose of the API? Metronidazole MW=171.16; Metronidazole Benzoate MW=275.26 Weigh _____________g of metronidazole benzoate powder on electronic balance. (Round appropriately.) 8. (3pts) Calculate the w/v% concentration of sodium hydroxide in this Liquid Caustic solution. 9. (3pts) You are preparing benzalkonium chloride 1:1,000 for use as a topical antiseptic. Your pharmacy has 1 fl oz of ZEPHIRAN (benzalkonium chloride) 17% w/v solution in stock. If you used the whole fluid ounce of solution, how many liters of the antiseptic solution could you make? 10. (3pts) You prepare 500ml of 3% w/v phosphoric acid solution by mixing 85% w/w phosphoric acid (SG of solution=1.7) with purified water. How many milliliters of the acid solution do you need? Indicate what size of graduated cylinder you will use. Round appropriately. 1 RX 351 Lab - Module 7 Assignment (20pts) Name _______________________________________________________________ Complete and submit on Canvas. You must show all work to receive full credit. Do not leave off units and make sure to use leading zeros. Dropping units in your answer or failure to use a leading zero in an answer will result in no credit for that answer, even if the number itself is correct. 1. (20pts) A 35-year-old man addicted to morphine is in the early stages of withdrawal, with diaphoresis and extreme agitation. His doctor ordered an injection of Myer’s Cocktail, a combination of vitamins and minerals to mitigate the withdrawal symptoms. Prepare one dose (25ml) of the formulation for this patient. Rx Calcium (elemental) 23.25mg Magnesium (elemental) Vitamin B12 (cyanocobalamin) Pyridoxine Dexpanthenol (Vitamin B5) Vitamin C (ascorbic acid) SWFI 95.15mg 750mcg 150mg 250mg 4.44g qs 25ml Administration: Inject over 15 minutes through a 25G needle SOURCES OF APIs Calculated Volume Syringe Size Measured Volume Note that the injection solution contains the dihydrate form calcium chloride. Atomic Weights: Ca=40; Cl=35.5; H=1; O=16 Note that the injection solution contains the hexahydrate form of magnesium chloride. Atomic Weights: Mg = 24.3 Cl=35.5; H=1; O = 16 Give answers for both ingredients. Can use 2 syringes to obtain necessary volume. 1
Answered 1 days AfterMar 26, 2023

Answer To: RX 351 Lab - Module 6 Assignment (30pts) Name...

Dr. Saloni answered on Mar 28 2023
31 Votes
RX 351 Lab - Module 6 Assignment (30pts)
Name _______________________________________________________________
Complete and submit on Canvas. You must show all work to receive full credit. Do not leave off units and make sure to use leading zeros. Dropping units in your answer or failure to use a leading zero in an answer will result in no credit for that answer, even if t
he number itself is correct.
Metronidazole is an antibiotic that is used orally, intravenously and topically. When compounding a pediatric oral suspension, it is typical to use metronidazole tablets as the source of the API, like in this formulation:
    Rx
    Metronidazole 500mg tablets
Chocolate Flavoring
Dark Cherry Flavoring
Bitter Suppressant
    #10
5gtts
5gtts
2gtts
    Ora-Blend Vehicle
    qs ad 100ml
1. (2pts) How many metronidazole 500mg tablets would you need to prepare 8 fluid ounces of this suspension?
Answer
To prepare 8 fluid ounces (236.6 mL) of the metronidazole oral suspension using 500 mg tablets as the source of the API, you would need a total of 5 tablets of metronidazole. Here is the calculation to show how this is determined:
First, we need to determine the concentration of the metronidazole suspension. Each 500 mg tablet will be dissolved in enough Ora-Blend vehicle to make 50 mL of suspension. Therefore, each 50 mL of suspension contains 500 mg of metronidazole.
To prepare 236.6 mL (8 fl oz) of the suspension, we can divide the total volume needed by the volume of each 50 mL suspension prepared from one tablet:
236.6 mL / 50 mL = 4.732
This means we need 4.732 portions of the 50 mL suspension.
Since each portion of the 50 mL suspension is prepared from one tablet, we need to round up the number of portions to the nearest whole number to ensure we have enough tablets. Therefore, we need to use 5 tablets of metronidazole to prepare 8 fluid ounces of the suspension.
So, to prepare 8 fluid ounces of the metronidazole oral suspension, you would need 5 metronidazole 500 mg tablets.
2. (2pts) If a pediatric patient takes ½ teaspoonful of this oral suspension q8h, how many milligrams of metronidazole will she receive per day?
Answer
To calculate how many milligrams of metronidazole the pediatric patient will receive per day, we can first determine the amount of metronidazole in each 1/2 teaspoonful of the suspension, and then calculate how much this amounts to over a 24-hour period:
First, we need to determine the amount of metronidazole in 1/2 teaspoonful of the suspension. We can use the total volume of the suspension (100 mL) and the total amount of metronidazole (5000 mg, from the 10 tablets) to calculate the concentration of the suspension:
Concentration = Total amount of metronidazole / Total volume of suspension
= 5000 mg / 100 mL
= 50 mg/mL
This means that each mL of the suspension contains 50 mg of metronidazole.
Since 1 teaspoonful is equivalent to 5 mL, 1/2 teaspoonful is equivalent to 2.5 mL. Therefore, 1/2 teaspoonful of the suspension contains:
2.5 mL x 50 mg/mL = 125 mg of metronidazole
The patient is taking 1/2 teaspoonful of the suspension every 8 hours, which means she is taking it three times a day. Therefore, the total amount of metronidazole she is taking per day is:
125 mg x 3 = 375 mg
So, the pediatric patient will receive 375 mg of metronidazole per day by taking 1/2 teaspoonful of the oral suspension every 8 hours.
3. (8pts) Refer to your textbook, Contemporary Pharmacy Practice, and read the sections on mortars and pestles in Chapter 13. Describe the different types of mortars.
Answer
Wedgwood mortar and pestle: This type of mortar is made of unglazed porcelain, and it is commonly used for mixing small quantities of substances. The unglazed surface of the mortar...
SOLUTION.PDF

Answer To This Question Is Available To Download

Related Questions & Answers

More Questions »

Submit New Assignment

Copy and Paste Your Assignment Here