Answer To: RX 351 Lab - Module 6 Assignment (30pts) Name...
Dr. Saloni answered on Mar 28 2023
RX 351 Lab - Module 6 Assignment (30pts)
Complete and submit on Canvas. You must show all work to receive full credit. Do not leave off units and make sure to use leading zeros. Dropping units in your answer or failure to use a leading zero in an answer will result in no credit for that answer, even if the number itself is correct.
Metronidazole is an antibiotic that is used orally, intravenously and topically. When compounding a pediatric oral suspension, it is typical to use metronidazole tablets as the source of the API, like in this formulation:
Metronidazole 500mg tablets
Dark Cherry Flavoring
qs ad 100ml
1. (2pts) How many metronidazole 500mg tablets would you need to prepare 8 fluid ounces of this suspension?
To prepare 8 fluid ounces (236.6 mL) of the metronidazole oral suspension using 500 mg tablets as the source of the API, you would need a total of 5 tablets of metronidazole. Here is the calculation to show how this is determined:
First, we need to determine the concentration of the metronidazole suspension. Each 500 mg tablet will be dissolved in enough Ora-Blend vehicle to make 50 mL of suspension. Therefore, each 50 mL of suspension contains 500 mg of metronidazole.
To prepare 236.6 mL (8 fl oz) of the suspension, we can divide the total volume needed by the volume of each 50 mL suspension prepared from one tablet:
236.6 mL / 50 mL = 4.732
This means we need 4.732 portions of the 50 mL suspension.
Since each portion of the 50 mL suspension is prepared from one tablet, we need to round up the number of portions to the nearest whole number to ensure we have enough tablets. Therefore, we need to use 5 tablets of metronidazole to prepare 8 fluid ounces of the suspension.
So, to prepare 8 fluid ounces of the metronidazole oral suspension, you would need 5 metronidazole 500 mg tablets.
2. (2pts) If a pediatric patient takes ½ teaspoonful of this oral suspension q8h, how many milligrams of metronidazole will she receive per day?
To calculate how many milligrams of metronidazole the pediatric patient will receive per day, we can first determine the amount of metronidazole in each 1/2 teaspoonful of the suspension, and then calculate how much this amounts to over a 24-hour period:
First, we need to determine the amount of metronidazole in 1/2 teaspoonful of the suspension. We can use the total volume of the suspension (100 mL) and the total amount of metronidazole (5000 mg, from the 10 tablets) to calculate the concentration of the suspension:
Concentration = Total amount of metronidazole / Total volume of suspension
= 5000 mg / 100 mL
= 50 mg/mL
This means that each mL of the suspension contains 50 mg of metronidazole.
Since 1 teaspoonful is equivalent to 5 mL, 1/2 teaspoonful is equivalent to 2.5 mL. Therefore, 1/2 teaspoonful of the suspension contains:
2.5 mL x 50 mg/mL = 125 mg of metronidazole
The patient is taking 1/2 teaspoonful of the suspension every 8 hours, which means she is taking it three times a day. Therefore, the total amount of metronidazole she is taking per day is:
125 mg x 3 = 375 mg
So, the pediatric patient will receive 375 mg of metronidazole per day by taking 1/2 teaspoonful of the oral suspension every 8 hours.
3. (8pts) Refer to your textbook, Contemporary Pharmacy Practice, and read the sections on mortars and pestles in Chapter 13. Describe the different types of mortars.
Wedgwood mortar and pestle: This type of mortar is made of unglazed porcelain, and it is commonly used for mixing small quantities of substances. The unglazed surface of the mortar...